Status:
COMPLETED
Perioperative Inflammation and Cyclooxygenase 2 (COX-2)
Lead Sponsor:
University of Washington
Collaborating Sponsors:
Pfizer
Conditions:
Neurosurgery
Pain
Eligibility:
All Genders
18-80 years
Phase:
PHASE4
Brief Summary
Surgery initiates a complex cascade of events involving the release of chemical compounds from nerve endings and damaged tissue which leads to an inflammatory and pain response. The purpose of this in...
Detailed Description
Surgery initiates a complex cascade of events involving the release of nociceptive compounds from nerve endings and damaged tissue which leads to an inflammatory and hyperalgesic response. COX-2 inhib...
Eligibility Criteria
Inclusion
- Patients undergoing surgery requiring lumbar drain placement
Exclusion
- Contraindication to COX-2 inhibitor (renal or hepatic insufficiency)
- Known adverse reaction to nonsteroidal anti-inflammatory drugs (NSAIDs)
- Use of NSAID or COX-2 within 7 days prior to surgery
Key Trial Info
Start Date :
November 1 2002
Trial Type :
INTERVENTIONAL
End Date :
January 1 2006
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00122096
Start Date
November 1 2002
End Date
January 1 2006
Last Update
September 26 2008
Active Locations (1)
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1
University of Washington
Seattle, Washington, United States, 98195