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Status:

COMPLETED

Imatinib in Dermatofibrosarcoma Protuberans (DFSP)

Lead Sponsor:

Dermatologic Cooperative Oncology Group

Conditions:

Dermatofibrosarcoma

Eligibility:

All Genders

18+ years

Phase:

PHASE1

PHASE2

Brief Summary

The purpose of this study is to determine whether imatinib is effective in the treatment of primary and recurrent dermatofibrosarcoma protuberans (DFSP).

Detailed Description

This study is aimed to investigate the efficacy of imatinib (Glivec) in the treatment of primary and locally relapsed dermatofibrosarcoma protuberans (DFSP). DFSP is a cutaneous neoplasm well known fo...

Eligibility Criteria

Inclusion

  • Histological diagnosis of primary or recurrent dermatofibrosarcoma protuberans
  • Measurable tumor parameters (by magnetic resonance imaging \[MRI\])
  • Patient \>/= 18 years of age
  • ECOG performance status \< 3
  • Adequate organ function
  • Patients must be able to swallow capsules
  • Female patients of childbearing potential must have negative pregnancy test
  • Written, voluntary, informed consent; must include investigational use of tumor tissue biopsies.

Exclusion

  • Any evidence of distant metastases
  • Patient has received any other investigational agents within 28 days of first day of study drug dosing
  • Patient is \< 5 years free of another primary malignancy except basal cell skin cancer or cervical carcinoma in situ
  • Grade III/IV cardiac problems as defined by the New York Heart Association
  • Severe and/or uncontrolled medical disease
  • Known diagnosis of human immunodeficiency virus (HIV) infection

Key Trial Info

Start Date :

January 1 2004

Trial Type :

INTERVENTIONAL

End Date :

January 1 2007

Estimated Enrollment :

30 Patients enrolled

Trial Details

Trial ID

NCT00122473

Start Date

January 1 2004

End Date

January 1 2007

Last Update

July 29 2011

Active Locations (4)

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Page 1 of 1 (4 locations)

1

Skin Cancer Unit, German Cancer Research Center and Department of Dermatology, University Hospital of Mannheim

Mannheim, Baden-Wurttemberg, Germany, 68167

2

Department of Dermatology, ElbeKliniken - Klinikum Buxtehude

Buxtehude, Lower Saxony, Germany, 21614

3

Department of Dermatology, The Saarland University Hospital

Homburg/Saar, Saarland, Germany, 66424

4

Department of Dermatology, Martin-Luther-University Halle-Wittenberg

Halle, Saxony-Anhalt, Germany, 06097