Status:
COMPLETED
Loxapine and Weaning From Ventilator
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Respiratory Insufficiency
Psychomotor Agitation
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Patients may be very agitated during the weaning period from mechanical ventilation. Administration of loxapine, a neuroleptic that does not notably affect ventilatory drive, may help in obtaining an ...
Detailed Description
Mechanical ventilation is a life-saving procedure in critically ill patients. This procedure is however not devoid of risks and every effort should be made to shorten its duration. This is best accomp...
Eligibility Criteria
Inclusion
- Patients who are eligible for weaning from the respirator (FIO2 less than 50%; positive end expiratory pressure \[PEEP\] level less than 6 cmH2O)
- Patients whose agitation (according to accepted scores) during a weaning trial precludes extubation
Exclusion
- History of convulsions or epilepsy
Key Trial Info
Start Date :
December 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2006
Estimated Enrollment :
9 Patients enrolled
Trial Details
Trial ID
NCT00122733
Start Date
December 1 2005
End Date
December 1 2006
Last Update
July 23 2007
Active Locations (1)
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1
Service de Réanimation, Hopital Louis Mourier
Colombes, France, 92700