Status:
COMPLETED
Single Injection of Dexamethasone for Acute Bronchiolitis in Young Children
Lead Sponsor:
Khon Kaen University
Collaborating Sponsors:
National Research Council of Thailand
Conditions:
Bronchiolitis, Viral
Eligibility:
All Genders
4-24 years
Phase:
NA
Brief Summary
The purpose of this study was to determine whether a single intramuscular injection of dexamethasone decreased the duration of symptoms of acute bronchiolitis in young children.
Detailed Description
Acute bronchiolitis is an infection of the lower respiratory tract causing inflammation of the small airways, leading to bronchiolar obstruction. Corticosteroids are frequently prescribed as anti-infl...
Eligibility Criteria
Inclusion
- Aged 4 weeks - 24 months
- Has the first episode of wheezing within 7 days
- Has evidence of viral infection
- Requires hospital admission; criteria for admission include one of the following: age \< 3 months; respiratory rate \> 60 breaths/minute for age \< 12 months or 50 breaths/minute for \> or equal to 12 months; oxygen saturation in room air \< 95% and apathy or refuses feeding.
Exclusion
- Initial admission to intensive care unit
- Initial requirement for endotracheal intubation or mechanical ventilation
- A previous history of intubation
- A known history of asthma or response to the first dose of beta2 agonist nebulization
- A history of prematurity
- A history of bronchopulmonary dysplasia or chronic lung disease
- Underlying congenital heart disease or immunodeficiency
- Receives treatment of any form of corticosteroids within 2 weeks
- Has contraindication to corticosteroid treatment
Key Trial Info
Start Date :
April 1 2002
Trial Type :
INTERVENTIONAL
End Date :
September 1 2004
Estimated Enrollment :
170 Patients enrolled
Trial Details
Trial ID
NCT00122785
Start Date
April 1 2002
End Date
September 1 2004
Last Update
July 29 2005
Active Locations (1)
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1
Srinagarind Hospital, Khon Kaen University and Khon Kaen Hospital, Ministry of Public Health
Khon Kaen, Changwat Khon Kaen, Thailand, 40002