Status:
COMPLETED
Effect of Improved Oral Hygiene to Prevent Pneumonia in Hospitalized Patients
Lead Sponsor:
State University of New York at Buffalo
Collaborating Sponsors:
National Institute of Dental and Craniofacial Research (NIDCR)
Conditions:
Pneumonia
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
Recent studies have found that poor oral hygiene may foster the colonization of the oropharynx by potential respiratory pathogens in mechanically-ventilated (MV), intensive care unit (ICU) patients. T...
Detailed Description
Recent studies have found that poor oral hygiene may foster the colonization of the oropharynx by potential respiratory pathogens in mechanically-ventilated (MV), intensive care unit (ICU) patients. T...
Eligibility Criteria
Inclusion
- Patients included in this study will be those admitted to the trauma intensive care unit (TICU) of Erie County Medical Center (ECMC) hospital. All patients admitted to the TICU who are intubated and mechanically ventilated within 24-48 hours of admission will be eligible for study admission, with the exception of those demonstrating the following exclusion criteria: a) a witnessed aspiration (to eliminate patients with chemical pneumonitis); b) a confirmed diagnosis of post-obstructive pneumonia (e.g. advanced lung cancer); c) a known hypersensitivity to CHX; d) patients for whom consent can not be obtained; e) a diagnosed thrombocytopenia (platelet count less than 40 and/or a INR above 2) or other coagulopathy; f) a do not intubate order; g) children under the age of 18 years; h) Pregnant women; i) Legal incarceration; j) If transferred from another ICU; k) Those with oral mucositis; l) Those with immunosuppression (either-HIV or drug induced \[e.g. organ transplant patients or those on long term steroid therapy\]); m) Patients re-admitted to the TICU
- Comatose and intubated patients will be included since they represent patients at greatest risk for respiratory infection.
Exclusion
- Patients for whom consent can not be obtained.
Key Trial Info
Start Date :
March 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2007
Estimated Enrollment :
175 Patients enrolled
Trial Details
Trial ID
NCT00123123
Start Date
March 1 2004
End Date
November 1 2007
Last Update
May 5 2021
Active Locations (1)
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1
University of Buffalo, The State University of New York
Buffalo, New York, United States, 14214