Status:
COMPLETED
Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine
Lead Sponsor:
University of Oxford
Collaborating Sponsors:
Merck Sharp & Dohme LLC
Conditions:
Cardiovascular Disease
Eligibility:
All Genders
18-80 years
Phase:
PHASE3
Brief Summary
SEARCH is a randomised, double-blind, multi-centre United Kingdom (UK) trial of 12,064 patients with myocardial infarction (MI) prior to study entry which aims to demonstrate whether a more intensive ...
Detailed Description
In observational studies, lower blood cholesterol concentrations are associated with lower coronary risk, without any clear threshold below which lower levels are not associated with lower risk. Chole...
Eligibility Criteria
Inclusion
- Prior myocardial infarction
- Statin therapy indicated
- No clear indication for folic acid
Exclusion
- No clear contraindication to study treatments
- Screening plasma total cholesterol \<3.5 mmol/l in patient already on statin therapy, or \<4.5 mmol/l in patient not on statin therapy
- Chronic liver disease
- Severe renal disease or evidence of renal impairment
- Inflammatory muscle disease
- Concurrent treatment with fibrates or high-dose niacin
- Concurrent treatment with cyclosporin (or condition likely to result in organ transplantation and the need for cyclosporin), nefazodone, methotrexate, systemic azole antifungal or systemic macrolide antibiotics
- Child bearing potential
- No other predominant medical problem (other than coronary heart disease \[CHD\]) which might limit compliance with 5 years of study treatment
Key Trial Info
Start Date :
July 1 1998
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2008
Estimated Enrollment :
12064 Patients enrolled
Trial Details
Trial ID
NCT00124072
Start Date
July 1 1998
End Date
May 1 2008
Last Update
February 1 2012
Active Locations (1)
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1
CTSU, Richard Doll Building, University of Oxford
Oxford, Oxon, United Kingdom, OX3 7LF