Status:
COMPLETED
Transesophageal Magnetic Resonance Imaging (MRI) in Conjunction With Lipid Lowering Measures
Lead Sponsor:
Johns Hopkins University
Collaborating Sponsors:
Surgi-Vision Inc
Merck Sharp & Dohme LLC
Conditions:
Heart Diseases
Eligibility:
All Genders
18-85 years
Phase:
NA
Brief Summary
This research is being done to investigate the ability of an experimental imaging method - transesophageal magnetic resonance imaging (TEMRI), to detect the change in aortic atherosclerotic plaque bur...
Detailed Description
Using a new MRI coil developed by Hopkins researchers, the investigators are now able to image aortic atherosclerotic plaques in exquisite detail. This coil is placed into the esophagus via a small na...
Eligibility Criteria
Inclusion
- Age greater than 18 years
- Required to have documented atherosclerosis in at least 1 vascular territory defined as: at least moderate (\>3.9mm) aortic atherosclerosis seen on transesophageal echocardiography; or moderate coronary artery disease (\>50% lesion) in at least 1 coronary artery seen at cardiac catheterization; or \>50% carotid lesion seen on ultrasound; or clinically documented peripheral vascular disease.
Exclusion
- Patients could be on any statin therapy at entry, but not on a dose equivalent to or greater than 80mg of simvastatin.
- Patients with pacemakers, automated implanted cardioverter defibrillators (AICD), aneurysm clips, abnormal nasopharyngeal anatomy, active peptic ulcer disease, severe dysphagia, elevated baseline liver transaminases and serum creatinine (greater than 2 times the normal), decompensated congestive heart failure or inability to give informed consent.
Key Trial Info
Start Date :
August 1 2000
Trial Type :
INTERVENTIONAL
End Date :
April 1 2004
Estimated Enrollment :
72 Patients enrolled
Trial Details
Trial ID
NCT00125060
Start Date
August 1 2000
End Date
April 1 2004
Last Update
August 24 2017
Active Locations (1)
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1
Johns Hopkins - School of Medicine
Baltimore, Maryland, United States, 21287