Status:
COMPLETED
The Effect of Nebivolol on Insulin Sensitivity
Lead Sponsor:
Imperial College London
Collaborating Sponsors:
Foundation for Circulatory Health
Conditions:
Hypertension
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The purpose of this study is to conduct a randomised trial to compare the insulin sensitivity, 24 hour blood pressure profile, and tolerability of nebivolol plus a thiazide-like diuretic versus atenol...
Detailed Description
Retrospective studies of treated hypertensive cohorts have strongly implicated beta blocker therapy as increasing the risk of developing new-onset diabetes. This has led to the latest British Hyperten...
Eligibility Criteria
Inclusion
- Males or females aged 18 or above
- Blood pressure that meets any of the three following criteria:
- BP should be \<140/85 mmHg on a maximum of two anti-hypertensive drugs
Exclusion
- contraindications to beta-blockade
- contraindications to thiazide use
- if there was a history of asthma, diabetes, heart failure, bradycardia, atrial fibrillation, AV conduction disturbances
- concurrent treatment with verapamil \& dilitiazem
- childbearing women
- compelling indication for treatment with a beta blocker
- any condition that will interfere with the treatment or the patient's ability to complete the study
Key Trial Info
Start Date :
July 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2009
Estimated Enrollment :
54 Patients enrolled
Trial Details
Trial ID
NCT00125853
Start Date
July 1 2006
End Date
January 1 2009
Last Update
December 12 2019
Active Locations (1)
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1
Imperial College London
Paddington, London, United Kingdom, W2 1PG