Status:
TERMINATED
Potentiation of Procedural Motor Learning in Health and Disease
Lead Sponsor:
University Hospital Muenster
Conditions:
Stroke
Eligibility:
All Genders
18-80 years
Phase:
PHASE4
Brief Summary
The investigators plan to improve the learning of motor skills by pharmacological means (dopamine), and by noninvasive brain stimulation. They will study both healthy subjects and chronic stroke patie...
Detailed Description
Adaptive behavior requires procedural motor learning, i.e. the acquisition of motor skills. Procedural learning is particularly critical in the rehabilitation of chronic motor deficits after stroke. A...
Eligibility Criteria
Inclusion
- Healthy Volunteers:
- Normal neurological examination
- Mini Mental State Examination of \> 27
- Right handedness
- Stroke Patients:
- Cortical or subcortical stroke with an initial severe hemiparesis Medical Research Council (MRC) scale \< 2 that has recovered to a degree that patients are able to perform the proposed task (in general \> MRC 4.5, with low spasticity, work in progress on motor learning in stroke patients)
- At least 1 year post-stroke
- Mini Mental State Examination of \> 27
- Right-handedness
Exclusion
- Healthy Volunteers and Stroke Patients:
- No antipsychotic, antidepressant drugs, and drugs affecting the dopaminergic system.
Key Trial Info
Start Date :
July 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2013
Estimated Enrollment :
18 Patients enrolled
Trial Details
Trial ID
NCT00126087
Start Date
July 1 2005
End Date
January 1 2013
Last Update
January 21 2013
Active Locations (1)
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1
University of Münster, Department of Neurology
Münster, North Rhine-Westphalia, Germany, 48129