Status:
COMPLETED
Adjunctive Treatment With Doxycycline to Enhance the Durability of Endovascular Aortic Aneurysm Repair
Lead Sponsor:
The Foundation for Barnes-Jewish Hospital
Conditions:
Aortic Aneurysm
Eligibility:
All Genders
50+ years
Phase:
NA
Brief Summary
The durability of endovascular aneurysm repair (EVAR) has been limited by development of endoleaks which may be secondary to progressive aortic degeneration by matrix metalloproteases (MMP). Doxycycli...
Detailed Description
Patients will be consented and enrolled at the time of their clinic visit or admission to the hospital for a planned EVAR, in accordance with institutional review board guidelines. Demographic, risk f...
Eligibility Criteria
Inclusion
- Presence of an abdominal aortic aneurysm (AAA) with a maximum diameter of \> or = 4.5 cm
- Planned aneurysm exclusion with endoluminal stent graft (any brand)
Exclusion
- Known malignancy not to include prostate cancer or any history of cancer that has not had a recurrence in the last 5 years.
- Hypersensitivity to doxycycline or any of its components
- Pregnancy
- Ruptured AAA
- Extension of covered portion of the graft above the renal arteries
- Previous endoluminal aneurysm repair
Key Trial Info
Start Date :
March 1 2004
Trial Type :
INTERVENTIONAL
End Date :
July 1 2006
Estimated Enrollment :
75 Patients enrolled
Trial Details
Trial ID
NCT00126204
Start Date
March 1 2004
End Date
July 1 2006
Last Update
March 4 2010
Active Locations (1)
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1
Washington University School of Medicine / Barnes-Jewish Hospital
St Louis, Missouri, United States, 63110