Status:
COMPLETED
Health Effects of Diesel Exhaust in Asthmatic Patients: A Real-world Study in a London Street
Lead Sponsor:
Imperial College London
Collaborating Sponsors:
Health Effects Institute
Conditions:
Asthma
Eligibility:
All Genders
18-55 years
Phase:
NA
Brief Summary
Acute exposure to diesel exhaust under normal city conditions leads to a worsening of symptoms of asthma, with reduction in lung function in asthmatic nonsmoking adults, dependent on the exposure dose...
Detailed Description
The investigators will recruit 60 nonsmoking asthmatics of mild and of moderate severity. They will be exposed to Oxford St. or to Hyde Park for 2 hours each, at a walking pace. Real time exposure to ...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Subjects will be selected according to the current severity of their asthma; thirty from Steps 1 and 2 and thirty from Step 3 of the World Health Organization (WHO) Global Initiative for Asthma (GINA) asthma guidelines. These will include mild and moderate asthmatic states. Depending on baseline FEV1, subjects will undergo either a methacholine bronchial hyperresponsiveness assessment or airways reversibility testing. Subjects with normal FEV1 (\>80% predicted) or normal FEV1/FVC ratio will undergo methacholine challenge. Subjects with FEV1 \<80% predicted will undergo airways reversibility testing. Subjects must have either a PC20 of less than 8mg/ml methacholine, or improvement in FEV1 of 12% or more, following inhalation of short acting β-agonist (salbutamol 200μg from metered dose inhaler \[MDI\]). Skin prick testing will be conducted for common allergens (house dust mite, grass pollen, aspergillus fumigatus and cat hair). The results will only be for descriptive purposes, not as subject inclusion/exclusion criteria. Subjects may be atopic or non-atopic (according to history and allergy testing).
Exclusion
Key Trial Info
Start Date :
May 1 2003
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2006
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00127062
Start Date
May 1 2003
End Date
August 1 2006
Last Update
November 5 2019
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