Status:
COMPLETED
Treatment of Helminth co-Infection: Short-Term Effects on HIV-1 Progression Markers and Immune Activation
Lead Sponsor:
University of Washington
Collaborating Sponsors:
Kenya Medical Research Institute
University of Nairobi
Conditions:
HIV Infections
Helminthiasis
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Identifying methods to slow disease progression in patients with HIV-1 infection remains a top priority in many regions of the world. In many countries, medications known to slow progression are not r...
Detailed Description
Many HIV infected individuals live in crowded urban settings. These conditions are associated with repeated intestinal parasite infections (helminths), which may alter the immune system in individuals...
Eligibility Criteria
Inclusion
- Participants must not be or have been on highly active antiretroviral therapy.
- Participants must have a CD4 count greater than 250 cells/mm3.
- Participants must be at least 18 years of age.
- Participants must be able and willing to participate and give written informed consent.
- Participants must be able and willing to return for the scheduled follow-up visits.
- In addition, in order to be included in the treatment phase of the study, patients must have at least one stool specimen positive for a soil transmitted helminth.
Exclusion
- Participants who have received treatment for helminth infection in the past 6 months (by self report or chart review).
- Participants must not be pregnant at the time of treatment (by urine HCG testing).
- Participants who present with other serious co-morbidities such as severe anaemia, malaria or tuberculosis.
Key Trial Info
Start Date :
March 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2007
Estimated Enrollment :
234 Patients enrolled
Trial Details
Trial ID
NCT00130910
Start Date
March 1 2006
End Date
June 1 2007
Last Update
November 15 2007
Active Locations (1)
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1
Kenya Medical Research Institute
Nairobi, Kenya