Status:
COMPLETED
Dose Comparison Study of Topiramate in Pediatric Subjects With Basilar/Hemiplegic Migraine
Lead Sponsor:
Monarch Medical Research
Collaborating Sponsors:
Ortho-McNeil Neurologics, Inc.
Conditions:
Basilar Migraine
Eligibility:
All Genders
6-18 years
Phase:
PHASE2
PHASE3
Brief Summary
The objective of this study is to assess the effectiveness and safety of topiramate in the prevention of basilar and hemiplegic migraine in children and adolescents.
Detailed Description
The objective of this study is to assess the efficacy and safety of topiramate in the prophylaxis of basilar migraine and hemiplegic migraine in children and adolescents, by comparing two doses, 25 an...
Eligibility Criteria
Inclusion
- Must meet International Headache Society (IHS) classification of pediatric migraine with aura: familial hemiplegic migraine (International Classification of Headache Disorders \[ICHD\] 1.2.4), sporadic hemiplegic migraine (ICHD 1.2.5) or basilar-type migraine (ICHD 1.2.6).
- Average of 4 migraine-days/month during the 3 months prior to screening.
- 4 migraine-days during prospective baseline period.
- At least one of the subject's migraines during the previous 3 months must have been accompanied by their characteristic basilar-type or hemiplegic neurologic symptoms of moderate to severe degree.
- 6-18 years of age.
- Weigh more than 25 kg.
- If female, subjects must:
- be premenarchal or otherwise incapable of pregnancy, or
- have practiced one of the following methods of contraception for at least one month prior to study entry: hormonal contraceptives, spermicide and barrier, intrauterine device, spousal/partner sterility, or
- be practicing abstinence and agree to continue abstinence or to use an acceptable method of contraception (as listed above) should sexual activity commence.
- If (b) or (c), the subject must have a negative urine pregnancy test within one week of study entry.
- Able to take oral medication in tablet form
- Willing and able to:
- read and comprehend written instructions,
- complete the assessment forms,
- return for regular visits, and d) adhere to medication regimens.
Exclusion
- Previously failed topiramate therapy for migraine prophylaxis or those who discontinued topiramate due to adverse events.
- Have taken topiramate within 14 days prior to the start of the prospective baseline period.
- Have 15 or more headache-days during the prospective baseline period.
- Have cluster headaches or chronic migraine.
- Have migraine aura without headache exclusively.
- Currently have a more painful condition than their migraine pain.
- Have taken any medications for migraine prophylaxis, within 2 weeks of the start of the prospective baseline period.
- Progressive neurological disorders or a structural disorder of the brain
- Overuse analgesic or migraine-specific agents for abortive treatment of migraine:
- \>10 treatment days/month of ergot-containing medication, triptans, or opioids;
- \>15 treatment days/month with simple analgesics (including NSAIDs)
- Require any injections of corticosteroids or local anesthetics within 60 days of visit 1 or botulinum toxin within 120 days prior to Visit 1.
- Have previously failed more than 2 adequate trials of an established prophylactic anti-migraine regimen.
- Subjects starting non-pharmacologic prophylactic approaches within 1 month prior to Visit 1. Non-pharmacologic prophylactic approaches started at least 1 month prior to Visit 1 should be continued throughout the study.
- Have taken carbonic anhydrase inhibitors or triamterene within 1 month prior to Visit 1.
- History of nephrolithiasis.
- Require continuing treatment with anticonvulsant therapy for a non-migraine condition.
- Significant major psychiatric disorder (e.g., major depression) or subjects receiving anti-psychotic medication.
- History of attempted suicide or suicidal tendencies.
- History of substance abuse.
- Pregnant or lactating females.
- Clinically unstable neurological, cardiovascular, gastrointestinal, musculoskeletal, pulmonary or other disease.
- Active liver disease.
- AST and/or ALT levels greater than 2 times the upper limit of normal range.
- Received an investigational drug or used an investigational device within 30 days of study entry.
Key Trial Info
Start Date :
February 1 2004
Trial Type :
INTERVENTIONAL
End Date :
August 1 2006
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00131443
Start Date
February 1 2004
End Date
August 1 2006
Last Update
November 12 2012
Active Locations (1)
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1
Monarch Medical Research - Child and Adolescent Neurology
Norfolk, Virginia, United States, 23510