Status:
COMPLETED
Training for Diagnosing Neurological Disorders
Lead Sponsor:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Musculoskeletal Physiology
Eligibility:
All Genders
18-120 years
Brief Summary
This training protocol has two objectives: 1) to train NINDS fellows in specialized techniques for diagnosing neurological disorders, and 2) to gather data from healthy volunteers and from patients wi...
Detailed Description
Objective: This is a training protocol. The goal of this protocol is to train fellows in advanced physiological techniques used for diagnosing neurological disorders. A secondary objective of the prot...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA FOR PATIENTS:
- Adult patients, over age 18 years old, with a clinical indication for the diagnostic procedures will be enrolled
- Suspected disorders of neuromuscular transmission, such as myasthenia gravis or
- Suspected Central demyelinating disorders such as multiple sclerosis or
- Suspected Myelopathy or
- Suspected motor neuron disease or
- Suspected Movement disorders that impair intracortical processes or
- Suspected neuropathy or myopathy or
- Suspected autonomic dysfunction
- INCLUSION CRITERIA FOR HEALTHY VOLUNTEERS:
- Healthy adults, aged 18 years or older, willing to participate
- EXCLUSION CRITERIA FOR PATIENTS:
- Patients with implanted devices, such as pacemakers, or metal in the cranium (excluding dental work) will be excluded from magnetic stimulation studies.
- Children under age 18 will be excluded, since the goal of this protocol is to provide training experience.
- Subjects who are unable to provide informed consent
- Persons undergoing the autonomic testing will be asked to refrain from smoking, caffeine, alcohol and vigorous exercise 24 hours before the study. Several medications should not be taken 48 hours prior to the study; these include tricyclic antidepressants, antihistamines, cough and cold medications, anti-Parkinson medication, muscle relaxants, anti-psychosis medications, opioid drugs, and blood pressure medications. No one is to stop their prescribed medication without discussion with their primary care physician though the ability to complete all of the autonomic testing may be affected.
- EXCLUSION CRITERIA FOR HEALTHY VOLUNTEERS:
- Medical conditions that require medications that affect the physiological measures being tested
- History of stroke, peripheral neuropathy or spine surgery
- Implanted devices or metal in the cranium (except dental work) if undergoing magnetic stimulation
- Persons undergoing the autonomic testing will be asked to refrain from smoking, caffeine, alcohol and vigorous exercise 24 hours before the study. Several medications should not be taken 48 hours prior to the study; these include tricyclic antidepressants, antihistamines, cough and cold medications, anti-Parkinson's medication, muscle relaxants, anti-psychosis medications, opioid drugs, and blood pressure medications. No one is to stop their prescribed medication without discussion with their primary care physician and you may be excluded from the study.
- NIH employees and staff may participate, except if they are EMG Section, OCD, NINDS employees.
Exclusion
Key Trial Info
Start Date :
November 4 2005
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 25 2021
Estimated Enrollment :
241 Patients enrolled
Trial Details
Trial ID
NCT00132353
Start Date
November 4 2005
End Date
January 25 2021
Last Update
January 26 2021
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892