Status:
COMPLETED
Effect of Leukoreduced Blood Transfusions on Infection Following Trauma
Lead Sponsor:
University of Washington
Collaborating Sponsors:
National Institutes of Health (NIH)
Conditions:
Wounds and Injuries
Eligibility:
All Genders
18+ years
Phase:
PHASE2
PHASE3
Brief Summary
The purpose of this study is to determine if leukoreduced blood transfusions reduce the risk of infection following trauma. Specifically, the investigators intend to evaluate whether there are clinica...
Detailed Description
Many severely injured patients survive their initial resuscitation only to suffer the late sequelae of nosocomial infection and multiple organ failure. The depth of hemorrhagic shock and the severity ...
Eligibility Criteria
Inclusion
- Trauma patients
- Age \> 17
- Transfusion within 24 hours of injury
Exclusion
- Active infection at time of injury
- Anticipated survival of \< 48 hours (e.g. gunshot wound \[GSW\] to head, cardiopulmonary resuscitation \[CPR\] in progress)
- Receipt of blood products for this injury event prior to randomization
- AB negative; B negative blood type.
- Positive antibody screen
- Prior requirement for irradiated, leukoreduced or cytomegalovirus (CMV) seronegative blood products
- Incarcerated
- Enrolled in pre-hospital trial
Key Trial Info
Start Date :
February 1 2003
Trial Type :
INTERVENTIONAL
End Date :
September 1 2004
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT00135291
Start Date
February 1 2003
End Date
September 1 2004
Last Update
January 11 2008
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Harborview Medical Center
Seattle, Washington, United States, 98004