Status:
COMPLETED
Stem Cells in Myocardial Infarction
Lead Sponsor:
Rigshospitalet, Denmark
Conditions:
Acute Myocardial Infarction
Eligibility:
All Genders
20-70 years
Phase:
PHASE2
Brief Summary
The purpose of this trial is to investigate the effect of treatment with granulocyte-colony stimulating factor (G-CSF) bone marrow stimulation on circulating stem cells' ability to develop new blood v...
Detailed Description
Intracoronary infusion of bone-marrow stem cells after a ST elevation myocardial infarction (STEMI) seems to improve cardiac function. An alternative strategy is increase of circulating stem cells by ...
Eligibility Criteria
Inclusion
- Patients between 20 and 70 years with STEMI were eligible if they had a successful PCI within 12 hours after onset of symptoms.
- The target lesion had to be located in the proximal section of the left anterior descending (LAD), left circumflex (LCX) or right coronary artery (RCA).
- Only patients with creatine kinase \[CK\]-MB \>100 microgram/L or development of Q waves in the electrocardiogram were included.
Exclusion
- Ventricular arrhythmia after PCI requiring treatment
- Pregnancy
- Unprotected left main stem lesion
- History of prior myocardial infarction
- Diagnosed or suspected cancer
- New York Heart Association (NYHA) class 3-4
- Known severe claustrophobia
- Significant stenosis in another coronary vessel than the acutely treated vessel, that might demand treatment with PCI or coronary artery bypass graft surgery (CABG) prior to the last follow-up exam.
Key Trial Info
Start Date :
May 1 2003
Trial Type :
INTERVENTIONAL
End Date :
February 1 2006
Estimated Enrollment :
78 Patients enrolled
Trial Details
Trial ID
NCT00135928
Start Date
May 1 2003
End Date
February 1 2006
Last Update
August 8 2011
Active Locations (1)
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1
2014 Department of Cardiology, The Heart Centre, University Hospital Rigshospitalet
Copenhagen, Denmark, 2100