Status:
UNKNOWN
Israel Multicenter D-Serine Study (IMSER) for the Treatment of Schizophrenia
Lead Sponsor:
Sheba Medical Center
Collaborating Sponsors:
Stanley Medical Research Institute
Conditions:
Schizophrenia
Schizoaffective Disorder
Eligibility:
All Genders
18-64 years
Phase:
PHASE2
Brief Summary
The goal of the present study is to evaluate the effect of D-serine, added to antipsychotic treatment, on negative and cognitive symptoms in schizophrenia. The investigators are hypothesizing that D-...
Eligibility Criteria
Inclusion
- Diagnostic and Statistical Manual of Mental Disorders - Fourth Edition (DSM-IV) diagnosis of schizophrenia and\\or schizoaffective disorder.
- Age between 18 to 64.
- PANSS negative symptom score higher than 19.
- SAS total score lower than 12.
- CDSS suicidal risk lower than 2
Exclusion
- Epilepsy
- Meets DSM-IV criteria for mental retardation.
- Medical condition which confounds presentation or treatment (e.g. uncontrolled diabetes mellitus, history of kidney stones, acute drug toxicity, dementia, delirium, stroke, etc.)
- Meets DSM-IV criteria for alcohol or drug dependence in last 6 months.
- Meets DSM-IV criteria for alcohol or drug abuse in last one month.
- Treatment with clozapine.
- Current positive pregnancy test or not using acceptable method of birth control.
- Meets DSM-IV criteria for current anxiety or mood disorders
Key Trial Info
Start Date :
October 1 2004
Trial Type :
INTERVENTIONAL
End Date :
October 1 2007
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT00138775
Start Date
October 1 2004
End Date
October 1 2007
Last Update
December 27 2006
Active Locations (14)
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1
Mazra Mental Health Center
Acre, Israel
2
Ha-Emek Medical Center
Afula, Israel
3
Abarbanel Mental Health Center
Bat Yam, Israel
4
Beer-Yaacov Mental Health Center
Beer-Yaacov, Israel