Status:
COMPLETED
TBTC Study 27: Moxifloxacin vs Ethambutol for TB Treatment
Lead Sponsor:
Centers for Disease Control and Prevention
Conditions:
Tuberculosis, Pulmonary
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
This study is a placebo-controlled factorial study, randomized to study drug (moxifloxacin vs. ethambutol) and treatment frequency (daily vs. thrice weekly after an initial two weeks of daily therapy)...
Detailed Description
The primary objective of this Phase II clinical trial is to compare the safety and microbiological activity of a moxifloxacin-containing regimen (isoniazid, rifampin, pyrazinamide, moxifloxacin \[HRZM...
Eligibility Criteria
Inclusion
- Suspected pulmonary tuberculosis with acid-fast bacilli in a stained sputum smear - patients whose sputum cultures do not grow M. tuberculosis and those having an M. tuberculosis isolate resistant to rifampin will be discontinued from the study, but followed for 14 days to detect late toxicities from study therapy. Patients having extra-pulmonary manifestations of tuberculosis, in addition to smear-positive pulmonary disease, are eligible for enrollment.
- Willingness to have HIV testing performed, if HIV serostatus is not known or if the last documented negative HIV test was more than 6 months prior to enrollment
- 7 or fewer days of tuberculosis therapy in the 6 months preceding enrollment
- Age \> 18 years
- Karnofsky score of at least 60
- Signed informed consent
- Women with child-bearing potential must agree to practice an adequate (barrier) method of birth control or to abstain from heterosexual sex.
- Laboratory parameters within 14 days of enrollment:
- Serum amino aspartate transferase (AST) activity less than 3 times the upper limit of normal
- Serum total bilirubin level less than 2.5 times upper limit of normal
- Serum creatinine level less than 2 times upper limit of normal
- Hemoglobin level of at least 7.0 g/dL
- Platelet count of at least 50,000/mm3
- Serum potassium \> 3.0 meq/L
- Negative pregnancy test (for women of childbearing potential)
Exclusion
- Breast-feeding
- Known intolerance to any of the study drugs
- Known allergy to any fluoroquinolone antibiotic
- Current or planned therapy during the first 2 months of tuberculosis treatment using drugs having unacceptable interactions with rifampin (rifabutin can be substituted for rifampin during the continuation phase of therapy)
- Current or planned antiretroviral therapy during the first 2 months of tuberculosis treatment
- History of prolonged QT syndrome or current or planned therapy with quinidine, procainamide, amiodarone, sotalol, or ziprasidone during the first 2 months of tuberculosis treatment.
- Pulmonary silicosis
Key Trial Info
Start Date :
July 1 2003
Trial Type :
INTERVENTIONAL
End Date :
December 1 2005
Estimated Enrollment :
350 Patients enrolled
Trial Details
Trial ID
NCT00140309
Start Date
July 1 2003
End Date
December 1 2005
Last Update
March 19 2007
Active Locations (23)
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1
University of Southern California Medical Center
Los Angeles, California, United States, 90033
2
University of California at San Diego
San Diego, California, United States, 92103
3
University of California, San Francisco
San Francisco, California, United States, 94110
4
Denver Public Health Department
Denver, Colorado, United States, 80204