Status:
COMPLETED
Age of Blood in Brain Injury
Lead Sponsor:
University of British Columbia
Conditions:
Traumatic Brain Injury
Eligibility:
All Genders
16+ years
Phase:
NA
Brief Summary
Donated red blood cells vary in how old they are, that is, how long they have been stored since being collected from donors. Blood that has been donated is stored for a maximum of 42 days, after this ...
Detailed Description
PURPOSE To demonstrate that packed red blood cells (pRBC) less than 5 days old are superior to older (\>20days) blood in improving markers of cerebral oxygenation in acutely head injured patients. H...
Eligibility Criteria
Inclusion
- Patients with primary traumatic brain injury
- Glasgow Coma Scale \< 8
- Invasive neurological monitoring:
- External Ventricular Drain
- Jugular bulb catheter
- Hemoglobin \< 100 g/L and decision has been made by Attending Physician to treat with one unit pRBC
Exclusion
- Age \< 16
- Ongoing need for blood products
- Received Packed Red Blood Cells within preceding 24 hours
- Multiple trauma necessitating ongoing resuscitation
- Pregnant patients
- Chronic renal failure
- Severe sepsis or septic shock
- Adult respiratory distress syndrome or acute lung injury
- Presumed unstable neurological status during course of study
- Lack of informed consent
Key Trial Info
Start Date :
March 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2007
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00141674
Start Date
March 1 2005
End Date
December 1 2007
Last Update
September 4 2008
Active Locations (1)
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1
Vancouver General Hospital
Vancouver, British Columbia, Canada, V5Z 1M9