Status:
NO_LONGER_AVAILABLE
Compassionate Use of Defibrotide for Patients With Veno-occlusive Disease of the Liver
Lead Sponsor:
St. Jude Children's Research Hospital
Conditions:
Hepatic Veno-occlusive Disease
Eligibility:
All Genders
Brief Summary
Veno-occlusive disease (VOD) of the liver is a significant complication for some patients undergoing hematopoietic stem cell transplantation. This disease is thought to be a toxicity secondary to chem...
Detailed Description
Secondary objectives of this protocol include the following: * To describe the toxicities of defibrotide in patients with VOD. * To describe the response rate of VOD in patients receiving defibrotide...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Patients with clinical or pathologic diagnosis of veno-occlusive disease. The following criteria will be used:
- Hyperbilirubinemia (greater than or equal to 2mg/dl) and two of the following: (hepatomegaly, ascites, or weight gain \[greater than or equal to 5% of baseline\]); OR,
- Patient who do not fulfill criteria in #1 but who have pathologic or radiographic evidence of VOD.
Exclusion
Key Trial Info
Start Date :
November 1 2003
Trial Type :
EXPANDED_ACCESS
End Date :
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00143546
Start Date
November 1 2003
Last Update
April 25 2017
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
St. Jude Children's Research Hospital
Memphis, Tennessee, United States, 38105