Status:
UNKNOWN
Genetic Risk for Attention Deficit Hyperactivity Disorder Expressed in Brain Functioning
Lead Sponsor:
UMC Utrecht
Collaborating Sponsors:
Netherlands Organisation for Scientific Research
Conditions:
Attention Deficit Hyperactivity Disorder
Eligibility:
MALE
8-20 years
Brief Summary
Poor inhibitory control has been proposed to be central to the cognitive deficits and symptomatology associated with Attention Deficit Hyperactivity Disorder (ADHD). ADHD is a highly heritable disorde...
Detailed Description
Poor inhibitory control has been proposed to be central to the cognitive deficits and symptomatology associated with Attention Deficit Hyperactivity Disorder (ADHD). ADHD is a highly heritable disorde...
Eligibility Criteria
Inclusion
- Age 8 - 20 years
- Male
- Inclusion Criteria for Patients with ADHD:
- DSM-IV (APA, 1994) diagnosis of ADHD, according to DISC interview
- Scores in the clinical range on the Child Behavior Checklist (CBCL) and Teacher Rating Form(TRF)
- One brother who meets the inclusion criteria for siblings
- Inclusion Criteria for Unaffected Siblings:
- No DSM-IV (APA, 1994) diagnosis according to DISC interview
- No scores in the clinical range on the Child Behavior Checklist (CBCL) and Teacher Rating Form (TRF)
- Inclusion Criteria for Controls:
- No DSM-IV (APA, 1994) diagnosis, according to DISC interview
- No scores in the clinical range on the Child Behavior Checklist (CBCL) and Teacher Rating Form (TRF)
Exclusion
- IQ \< 70
- Illness of the cardiovascular, the endocrine, the pulmonal or the gastrointestinal system
- Presence of metal objects in or around the body (pacemaker, dental braces)
- History of or present neurological disorder
- For individuals over 12 years of age: legal incompetence, defined as the obvious inability to comprehend the information that is presented by the investigator and is outlined in the Information letter and on which the decision to participate in the study is to be based
Key Trial Info
Start Date :
September 1 2004
Trial Type :
OBSERVATIONAL
End Date :
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT00143832
Start Date
September 1 2004
Last Update
March 20 2007
Active Locations (1)
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1
Dept. of Child and Adolescent Psychiatry, UMC Utrecht
Utrecht, Netherlands