Status:

UNKNOWN

Genetic Risk for Attention Deficit Hyperactivity Disorder Expressed in Brain Functioning

Lead Sponsor:

UMC Utrecht

Collaborating Sponsors:

Netherlands Organisation for Scientific Research

Conditions:

Attention Deficit Hyperactivity Disorder

Eligibility:

MALE

8-20 years

Brief Summary

Poor inhibitory control has been proposed to be central to the cognitive deficits and symptomatology associated with Attention Deficit Hyperactivity Disorder (ADHD). ADHD is a highly heritable disorde...

Detailed Description

Poor inhibitory control has been proposed to be central to the cognitive deficits and symptomatology associated with Attention Deficit Hyperactivity Disorder (ADHD). ADHD is a highly heritable disorde...

Eligibility Criteria

Inclusion

  • Age 8 - 20 years
  • Male
  • Inclusion Criteria for Patients with ADHD:
  • DSM-IV (APA, 1994) diagnosis of ADHD, according to DISC interview
  • Scores in the clinical range on the Child Behavior Checklist (CBCL) and Teacher Rating Form(TRF)
  • One brother who meets the inclusion criteria for siblings
  • Inclusion Criteria for Unaffected Siblings:
  • No DSM-IV (APA, 1994) diagnosis according to DISC interview
  • No scores in the clinical range on the Child Behavior Checklist (CBCL) and Teacher Rating Form (TRF)
  • Inclusion Criteria for Controls:
  • No DSM-IV (APA, 1994) diagnosis, according to DISC interview
  • No scores in the clinical range on the Child Behavior Checklist (CBCL) and Teacher Rating Form (TRF)

Exclusion

  • IQ \< 70
  • Illness of the cardiovascular, the endocrine, the pulmonal or the gastrointestinal system
  • Presence of metal objects in or around the body (pacemaker, dental braces)
  • History of or present neurological disorder
  • For individuals over 12 years of age: legal incompetence, defined as the obvious inability to comprehend the information that is presented by the investigator and is outlined in the Information letter and on which the decision to participate in the study is to be based

Key Trial Info

Start Date :

September 1 2004

Trial Type :

OBSERVATIONAL

End Date :

Estimated Enrollment :

90 Patients enrolled

Trial Details

Trial ID

NCT00143832

Start Date

September 1 2004

Last Update

March 20 2007

Active Locations (1)

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1

Dept. of Child and Adolescent Psychiatry, UMC Utrecht

Utrecht, Netherlands