Status:
COMPLETED
Therapy for Pediatric Hodgkin Lymphoma
Lead Sponsor:
St. Jude Children's Research Hospital
Conditions:
Hodgkin Lymphoma
Eligibility:
All Genders
Up to 21 years
Phase:
PHASE2
Brief Summary
With the success of current chemotherapy for Hodgkin's disease, the goal of this protocol is to maintain the currently successful cure rate and reduce treatment related side effects and long term toxi...
Detailed Description
This study will evaluate the following objectives: Primary Objectives: 1. To evaluate the efficacy of 4 cycles of VAMP chemotherapy alone in patients with favorable risk Hodgkin's disease who achiev...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Eligible patients must have histologically confirmed previously untreated Hodgkin's disease (Patients receiving limited emergent RT or steroid therapy because of cardiopulmonary decompensation or spinal cord compression will be eligible for protocol enrollment).
- Patients must be 21 years of age or younger
- Ann Arbor stages IIB-IV
- No prior treatment.
- No pregnant or lactating women.
- Signed informed consent
- If re-evaluation of a patient's disease shows favorable risk features or intermediate risk features, the patient will be removed from the HOD99 study and consented to the respective HOD08 or HOD05 study.
- Inclusion: treatment of favorable risk features:
- Ann Arbor IA or IIA with:
- Non-bulky mediastinal disease (\<33% mediastinal to thoracic ratio on chest x ray)
- Ann Arbor stage IA or IIA with any of the following features: (1) "E" lesions (s), (2) 3 or more nodal sites involved, (3) Bulky mediastinal adenopathy (mediastinal mass to thoracic cavity ratio 33% or greater by chest radiograph)
- Inclusion: unfavorable risk features:
- Stage must be classified as one of the following:
- Ann Arbor stage IIB, IIIB, or any IV
Exclusion
Key Trial Info
Start Date :
March 2 2000
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 5 2021
Estimated Enrollment :
296 Patients enrolled
Trial Details
Trial ID
NCT00145600
Start Date
March 2 2000
End Date
November 5 2021
Last Update
October 20 2022
Active Locations (5)
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1
Stanford University
Palo Alto, California, United States, 94304
2
Maine Children's Cancer Program
Portland, Maine, United States, 04102-3175
3
Dana Farber Cancer Institute
Boston, Massachusetts, United States, 02115
4
Massachusetts General Hospital
Boston, Massachusetts, United States, 02115