Status:
COMPLETED
Adult Stem Cell Therapy in Liver Insufficiency
Lead Sponsor:
Imperial College London
Conditions:
Liver Cirrhosis
Eligibility:
All Genders
20-65 years
Phase:
NA
Brief Summary
In order to determine the clinical application potential of adult stem cells we propose to investigate the safety and toxicity of infusing adult stem cells in the hepatic artery or portal vein of five...
Detailed Description
The liver in an adult healthy body maintains a balance between cell gain and cell loss. Though normally proliferatively quiescent, hepatocyte loss such as that caused by partial hepatectomy, uncomplic...
Eligibility Criteria
Inclusion
- \- Male or female aged from 20 years to 65 years Evidence of chronic liver failure Abnormal serum albumin and/or bilirubin and/or prothrombin time Unsuitable for liver transplantation WHO performance status \<2 Women of childbearing potential may be included but must use a reliable and appropriate contraceptive method Life expectancy of at least three months Ability to give informed consent
Exclusion
- \- Patients aged below 20 years or above 65 years Pregnant or lactating women Patients with recent recurrent gastrointestinal bleeding Spontaneous bacterial peritonitis Evidence of active infection HIV infection Patients unable to give informed consent
Key Trial Info
Start Date :
January 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2005
Estimated Enrollment :
5 Patients enrolled
Trial Details
Trial ID
NCT00147043
Start Date
January 1 2005
End Date
June 1 2005
Last Update
October 3 2019
Active Locations (1)
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1
Hammersmith Hospitals NHS Trust
London, United Kingdom, W12 0HS