Status:
COMPLETED
Effect of Sarpogrelate on Platelet Aggregation in Patients With Cerebral Infarction: Dose-responsive Clinical Pharmacology Study
Lead Sponsor:
Tanabe Pharma Corporation
Conditions:
Cerebral Infarction
Eligibility:
All Genders
Phase:
PHASE3
Brief Summary
Sarpogrelate is an antiplatelet agent that decreases 5-hydroxytryptamine( 5-HT )levels in platelets via blockade of 5-HT2 receptors, has been used in atherosclerotic peripheral arterial disease. The ...
Eligibility Criteria
Inclusion
- Cerebral infarction except cardiac source of embolism based on the NINDSⅢclassification
- Neurological signs persisting≧ 1 day from onset
- Defined onset of symptoms, and stable condition at the period of enrollment
- CT or MRI detection of responsible site
- age≧20
- Systolic pressure≦180 mmHg, Diastolic pressure≦110 mmHg
- The maximum intensity of platelet aggregation is above 15 % induced by serotonin (1µM) and epinephrine (3µM) on the day of prior to the first medication
- Written informed consent must be obtained from the patients before enrollment into the study
Exclusion
- Functional outcome at randomization: Modified Rankin Scale=4, 5
- Previous or planned for vascular surgery to cerebral infarction
- History of intracranial hemorrhage
- History of systemic bleeding, or other history of bleeding diathesis or coagulopathy
- With severe complications ( renal or hepatic insufficiency, heart failure, hemopathy, and so on )
- Treating malignant tumor
- Pregnant or possibly pregnant women, or nursing mothers
- History of sarpogrelate sensitivity
- Previously entered in other clinical trials within 3 months
- Less than 3 months since any other clinical trial
- Judged by investigator to be unsuitable for the study
Key Trial Info
Start Date :
April 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2005
Estimated Enrollment :
46 Patients enrolled
Trial Details
Trial ID
NCT00147303
Start Date
April 1 2004
End Date
January 1 2005
Last Update
April 10 2015
Active Locations (0)
Enter a location and click search to find clinical trials sorted by distance.
No Results Found
We couldn’t find results for the location/zipcode entered or within the selected range. Please check your input or adjust your search.