Status:
COMPLETED
Influence of Pravastatin on Carotid Artery Structure and Function in HIV-infected Patients Under Antiretroviral Therapy
Lead Sponsor:
Saint Antoine University Hospital
Collaborating Sponsors:
French Cardiology Society
Conditions:
HIV Infection
Carotid Atherosclerosis
Eligibility:
All Genders
30+ years
Brief Summary
The advent of new antiretroviral agents, in particular Highly Active Antiretroviral Therapy (HAART), spectacularly reduced HIV-associated morbidity and mortality. However, new complications have appea...
Eligibility Criteria
Inclusion
- HIV-infected patients treated with HAART for \> 12 months
- With dyslipidemia, defined as LDL cholesterol \> 160 mg/dL before initiation of statin
- Treated with pravastatin \> 12 months and one more coronary risk factor. The patients in the control group were selected consecutively in the same departments among
- HIV-infected patients treated with HAART \> 12 months
- LDL cholesterol \> 160 mg/dL
- Without lipid-lowering drugs and one more coronary risk factor. Cases and control patients were matched for age, gender and tobacco consumption.
Exclusion
- Patients with history of coronary artery disease, peripheral artery disease, endarterectomy, aortic dissection
Key Trial Info
Start Date :
May 1 2003
Trial Type :
OBSERVATIONAL
End Date :
June 1 2005
Estimated Enrollment :
84 Patients enrolled
Trial Details
Trial ID
NCT00147797
Start Date
May 1 2003
End Date
June 1 2005
Last Update
October 25 2016
Active Locations (1)
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1
Department of Pharmacology and INSERM U652, Hôpital Européen Georges Pompidou
Paris, France, 75015