Status:
COMPLETED
The Efficacy of Escitalopram for Negative Symptoms in Schizophrenia
Lead Sponsor:
BeerYaakov Mental Health Center
Collaborating Sponsors:
Lundbeck Israel
Conditions:
Schizophrenia
Eligibility:
All Genders
18-60 years
Phase:
PHASE3
Brief Summary
The aim of this study is to evaluate the therapeutic effect of escitalopram in the treatment of negative symptoms in schizophrenia patients in a double-blind placebo-controlled study.
Detailed Description
The aim of this study is to evaluate the therapeutic effect of escitalopram (cipralex) in the treatment of negative symptoms in schizophrenic patients receiving either typical or the newer atypical an...
Eligibility Criteria
Inclusion
- Chronic schizophrenia patients,
- Age \<60,
- Medicated,
- Inpatients and outpatients,on stable doses of antipsychotic medications for at least one month before the study entry.
- Patients will be clinically stable and free of any additional axis I diagnosis or significant medical illnesses before enrollment into the study.
- A Positive and Negative Syndrome Scale (PANSS) score of 50 or above will be required for entry to the study.
Exclusion
- Comorbidity with mania or major depression,
- Pregnancy,
- Lactation,
- Impaired renal or hepatic function,
- History of sensitivity to cipramil or to other drugs from the selective serotonin reuptake inhibitor (SSRI) group.
- Additional exclusion criteria will consist of mental retardation, organic conditions (brain tumors, drug abuse) and severe exacerbation of the psychiatric condition (i.e. suicide attempt, severe psychotic exacerbation) as defined by hospitalization in high-security units, clinical impression and CGI scores of "condition much worsened".
- Patients will be excluded during the study if they will remove their informed consent.
Key Trial Info
Start Date :
November 1 2004
Trial Type :
INTERVENTIONAL
End Date :
September 1 2005
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00148447
Start Date
November 1 2004
End Date
September 1 2005
Last Update
May 3 2007
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Iulian Iancu
Beer Yaakov, Israel, POB 1