Status:
COMPLETED
CHIZAP: Community- and Health Facility-Based Intervention With Zinc as Adjuvant Therapy for Childhood Pneumonia
Lead Sponsor:
Centre For International Health
Collaborating Sponsors:
Tribhuvan University, Nepal
Statens Serum Institut
Conditions:
Pneumonia
Eligibility:
All Genders
2-3 years
Phase:
PHASE2
PHASE3
Brief Summary
The aim of the study described is to measure the degree with which zinc given as adjunct therapy to standard antibiotic treatment during childhood pneumonia reduces the risk of treatment failure and t...
Detailed Description
Hypothesis: Zinc deficiency is a major public health problem in developing counties. Poor zinc status is associated with stunted growth and reduced resistance to infections. Several in vitro experimen...
Eligibility Criteria
Inclusion
- Pneumonia: Child presenting with cough or difficult breathing and elevated respiratory rate.
- Severe pneumonia: Child presenting with cough or difficult breathing and chest indrawing , but without any of the following danger signs:
- not able to drink/breastfeed,
- vomit everything,
- has had convulsions,
- is lethargic or unconscious.
- Must be able to take Zinc
Exclusion
- The child requires special care for severe illness other than pneumonia
- Severe malnutrition defined as being \< 70% National Center for Health Statistics (NCHS) median weight for height
- Presence of congenital heart disease
- Documented tuberculosis
- Any antibiotic treatment during the last 48 hours
- The child was enrolled less than 6 months ago
- Presence of dysentery
- Cough for more than 14 days
Key Trial Info
Start Date :
January 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2008
Estimated Enrollment :
2628 Patients enrolled
Trial Details
Trial ID
NCT00148733
Start Date
January 1 2004
End Date
January 1 2008
Last Update
March 16 2022
Active Locations (1)
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1
Siddhi Memorial Hospital (SMH),Bhelukhel, Bhimsensthan
Bhaktapur, Nepal, P.O.Box 40