Status:
UNKNOWN
Erythropoietin in Acute Myocardial Infarction
Lead Sponsor:
Hammersmith Hospitals NHS Trust
Conditions:
Acute Myocardial Infarction
Eligibility:
All Genders
18-80 years
Phase:
PHASE2
Brief Summary
Erythropoietin (EPO) is a naturally occuring hormone which regulates the body's response to lack of oxygen and controls the number of red cells in the blood. Recent studies in animals have shown that ...
Detailed Description
We wish to perform a randomised double-blind, placebo-controlled clinical trial to examine the effects of EPO given at the time of primary angioplasty for acute myocardial infarction (MI) on myocardia...
Eligibility Criteria
Inclusion
- Male or female \>18 years of age
- Weight between 50 kg and 120 kg
- Suspected of having his/her first-documented STEMI
- Symptoms of ischemia of \>20 min with \< 6h prior to PCI
- Either 1mm ST elevation in at least two contiguous limb leads or \>2mm ST elevation in 2 contiguous chest leads
- Primary PCI to occur within 8h from the onset of symptoms
- Women of childbearing potential must have a negative pregnancy test
Exclusion
- Contraindications to MRI scanning
- History or ECG evidence of previous STEMI
- Cardiogenic shock
- NYHA class III-IV heart failure
- LBBB or AF on ECG; 6.Major trauma, major surgery, eye, spinal cord, or brain surgery within the last 3 months
- Significant hepatic disturbance
- Chronic renal impairment (Creatinine \>200µmol/L)
- Stroke or TIA \<6 months
- Pregnancy or breast-feeding
- Dependence on alcohol or other DOA
- Significant psychiatric/neurologic disease that would prevent adherence to the requirements of the protocol
- Significant immunocompromise (including, but not limited to AIDS and immune-suppressive therapy
- Current treatment with human recombinant erythropoietin
- Current hemodialysis or peritoneal dialysis
Key Trial Info
Start Date :
October 1 2005
Trial Type :
INTERVENTIONAL
End Date :
January 1 2008
Estimated Enrollment :
124 Patients enrolled
Trial Details
Trial ID
NCT00149058
Start Date
October 1 2005
End Date
January 1 2008
Last Update
September 8 2005
Active Locations (2)
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1
Hammersmith Hospital NHS Trust
London, United Kingdom, W12 0HS
2
King's College London
London, United Kingdom, W12 0HS