Status:
COMPLETED
Pharmacogenetics of Disulfiram for Cocaine
Lead Sponsor:
Baylor College of Medicine
Collaborating Sponsors:
National Institute on Drug Abuse (NIDA)
Yale University
Conditions:
Cocaine Dependence
Opioid Dependence
Eligibility:
All Genders
18-64 years
Phase:
PHASE2
Brief Summary
Previous research has shown that disulfiram, a medication sometimes used for treating alcoholism, discourages cocaine use among cocaine addicts who are undergoing methadone treatment. By blocking the ...
Detailed Description
Dopamine, a type of neurotransmitter, is the brain's "feel good" chemical. The amount of dopamine in the body may be an important factor in how cocaine addicts respond to treatment. Disulfiram, like c...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Meets DSM-IV diagnosis criteria for opioid dependence, as determined by documentation of prior treatment for addiction; signs of withdrawal; self-reported history of dependence for at least 1 year; and a positive urine test for opioids
- Meets DSM-IV diagnosis criteria for cocaine dependence, as determined by self-reported use of cocaine at least once weekly for at least 1 month prior to study entry; a positive urine test for cocaine; and a score greater than 3 on the Severity Dependence Scale
- If female, willing to use contraception throughout the study
- Exclusion criteria:
- Meets DSM-IV diagnosis criteria for dependence on any drugs other than opiates, cocaine, or tobacco
- Current major psychiatric illness, including schizophrenia, bipolar disorder, or other psychotic disorder
- Current suicidal or homicidal ideation
- Current use of a prescribed psychotropic medication that cannot be discontinued
- History of or current major medical illness, including major heart, kidney, endocrine, or liver disorder; abnormal liver function (SGOT or SGPT levels three times greater than normal);
- High risk factor for heart disease, seizure disorders, or any illness for which disulfiram or methadone treatment would be inadvisable
- Currently taking metronidazole or clotrimazole
- Pregnant or breastfeeding
Exclusion
Key Trial Info
Start Date :
January 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2009
Estimated Enrollment :
93 Patients enrolled
Trial Details
Trial ID
NCT00149630
Start Date
January 1 2005
End Date
December 1 2009
Last Update
March 15 2017
Active Locations (1)
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1
Michael E. DeBakey VA Medical Center
Houston, Texas, United States, 77030