Status:
COMPLETED
Employment-based Reinforcement of Naltrexone Ingestion and Abstinence
Lead Sponsor:
Johns Hopkins University
Collaborating Sponsors:
National Institute on Drug Abuse (NIDA)
Conditions:
Cocaine-Related Disorders
Heroin Dependence
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
A randomized study is planned over 5 years to evaluate the effectiveness of the Therapeutic Workplace in promoting naltrexone ingestion and abstinence in unemployed opiate-dependent injection drug use...
Detailed Description
General Therapeutic Workplace Procedures The study was conducted in a model therapeutic workplace in which employment-based reinforcement contingencies are arranged to promote therapeutic behavior cha...
Eligibility Criteria
Inclusion
- Volunteers were eligible to participate if they
- were between the ages of 18 and 65 years,
- were unemployed (i.e., reporting no work in the past 30 days and earning $200 in taxable income per month),
- self-reported injection drug use and had visible track marks (assessed via visual inspection),
- provided a urine sample that tested positive for both opiates and cocaine upon entry into detoxification,
- met DSM-IV-TR criteria for opiate dependence,
- were medically approved to be maintained on naltrexone by the study physician,
- and lived within reasonable commuting distance to the research unit (i.e., in Baltimore City and the immediate surrounding area).
- Volunteers were excluded if they
- had active hallucinations, delusions, or a thought disorder;
- were judged to be of imminent threat to harm self or others;
- were currently incarcerated, in a halfway house, or under constant monitoring;
- were pregnant or breastfeeding;
- had serum aminotransferase levels over 3 times normal;
- required opiates for other medical problems (and thus could not be maintained on naltrexone, which would block the effects on any opiate);
- reported an interest in methadone treatment;
- had active tuberculosis;
- or had physical limitations that would prevent typing
Exclusion
Key Trial Info
Start Date :
December 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2010
Estimated Enrollment :
67 Patients enrolled
Trial Details
Trial ID
NCT00149669
Start Date
December 1 2005
End Date
December 1 2010
Last Update
September 14 2017
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
The Center for Learning and Health
Baltimore, Maryland, United States, 21224