Status:
COMPLETED
CCRT With Twice Weekly Paclitaxel and Cisplatin Followed by Surgery for Locally Advanced Esophageal Cancer
Lead Sponsor:
National Taiwan University Hospital
Conditions:
Esophageal Cancer
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
CCRT with twice weekly paclitaxel and cisplatin in patient with locally advanced esophageal cancer.
Detailed Description
The purpose of this study is to find out the clinical and pathological response rates of pre-operative concurrent chemoradiotherapy (CCRT) with twice weekly paclitaxel and cisplatin in patient with lo...
Eligibility Criteria
Inclusion
- Pathologically proven SCC or adenocarcinoma of esophagus .
- Locally advanced esophageal cancer , defined as T3 and/or N1 disease.( AJCC 1998)
- M1a disease defined ( AJCC 1998) , including celiac lymph node for lower thoracic esophageal cancer and cervical lymph node involvement for upper thoracic esophageal cancer .
- Age ≧ 18 ys
- KPS ≧ 60%
- Hemogram : WBC ≧ 4000/mm3 or ANC ≧ 2000 /mm3 and Platelet ≧ 100,000/mm3 . Biochemistry : GOT/GPT ≦ 3.5 times , Cr ≦ 1.5 mg/dl and Bilirubin ≦ 2.0 mg/dl .
Exclusion
- Invasion to surrounding organ ( T4 disease ) .
- Distant metastasis , except M1a disease .
- Patients who refuse operation .
Key Trial Info
Start Date :
August 1 2001
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2004
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00154804
Start Date
August 1 2001
End Date
April 1 2004
Last Update
August 23 2007
Active Locations (1)
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1
Department of Oncology, Nationa Taiwan University Hospital
Taipei, Taiwan