Status:
TERMINATED
Modification Of Disease Outcome In COPD
Lead Sponsor:
Leiden University Medical Center
Collaborating Sponsors:
Academisch Ziekenhuis Groningen
The Netherlands Asthma Foundation
Conditions:
Chronic Obstructive Pulmonary Disease
Eligibility:
All Genders
45-75 years
Phase:
PHASE4
Brief Summary
The hypothesis to be tested of this study is that treatment with fluticasone propionate leads to an initial improvement in symptoms, quality of life and lungfunction and a reduction in airways hyperre...
Detailed Description
Aim The primary aim of this study was to investigate whether short-term treatment with inhaled corticosteroids in COPD results in greater improvements in airway pathology, thereby leading to larger cl...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- COPD patients with \> 10 pack years.
- Written informed consent.
- Able to complete a diary card.
- At least one of the following symptoms: chronic cough, chronic sputum production, frequent exacerbations, or dyspnoea at exertion.
- Postbronchodilator FEV1 below 90% confidence interval of predicted and postbronchodilator FEV1/FVC below 90% confidence interval of predicted.
- Exclusion criteria:
- No oral corticosteroids 3 months prior to the study or maintenance treatment with corticostroids 6 months prior to the study.
- No history of asthma, lung diseases other than COPD, other diseases likely to interfere with the study.
Exclusion
Key Trial Info
Start Date :
April 1 2000
Trial Type :
INTERVENTIONAL
End Date :
May 1 2005
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT00158847
Start Date
April 1 2000
End Date
May 1 2005
Last Update
January 20 2006
Active Locations (2)
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1
University Medical Center Groningen
Groningen, Netherlands, 9700 RB
2
Leiden University Medical Center
Leiden, Netherlands, 2300 RC