Status:
COMPLETED
VAST - Ventricular Arrhythmia Suppression Trial
Lead Sponsor:
Boston Scientific Corporation
Conditions:
Tachycardia
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
The purpose of VAST is to determine whether the Rate Smoothing feature in Guidant's PRIZM/VITALITY-family ICDs has an effect on the incidence of ventricular tachyarrhythmias.
Eligibility Criteria
Inclusion
- Patients who receive a commercially available Guidant PRIZM, PRIZM 2, or VITALITY AVT ICD
- Patients who sign and date a Patient Informed Consent prior to study enrollment
- Patients who remain in the clinical care of physicians of their implanting center
Exclusion
- Patients who have chronic atrial fibrillation. Paroxysms of AF are not an exclusion criterion, but the patient must be in normal sinus rhythm at the time of randomization. If history of AF is unknown or uncertain, or the patient was recently cardioverted, there must be at least 23 hours of normal sinus rhythm within the 24 hour period preceding randomization
- Patients who previously had an ICD
- Patients with current indications for cardiac resynchronization therapy with defibrillation (CRT-D)
- Patients whose life expectancy is less than 12 months due to other medical conditions
- Patients who are expected to receive a heart transplant during the duration of the study
- Patients who have or who are likely to receive a tricuspid or other valve prosthesis
- Patients who are currently enrolled in another investigational study of active medical therapy. Each instance should be brought to Guidant's Clinical Application Research Studies (CARS) group to determine eligibility
- Patients who are younger than 18 years of age
- Patients who are mentally incompetent and cannot give a Patient Informed Consent or participate in the study
Key Trial Info
Start Date :
August 1 2003
Trial Type :
INTERVENTIONAL
End Date :
May 1 2005
Estimated Enrollment :
550 Patients enrolled
Trial Details
Trial ID
NCT00158912
Start Date
August 1 2003
End Date
May 1 2005
Last Update
November 22 2006
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