Status:
COMPLETED
Can Oral Vitamin B12 and Folate Supplementation Preserve Cognitive Function of Patients With Early Dementia?
Lead Sponsor:
Chinese University of Hong Kong
Conditions:
Dementia
Eligibility:
All Genders
60+ years
Phase:
PHASE4
Brief Summary
Background: Vitamin B12 and folate are essential to brain health. Sub optimal status of vitamin B12 and folate leads to elevation of plasma homocysteine concentration, which is associated with Dementi...
Detailed Description
After stratified randomization by mini mental state examination scores, supplement group subjects take 1 mg of methylcobalamin and 5 mg of folic acid daily, while placebo group subjects take placebo c...
Eligibility Criteria
Inclusion
- Dementia of Alzheimer's or vascular type
- Early dementia defined by Clinical Dementia Rating of 1.
Exclusion
- lives alone
- significant communication problems
- significant co-existing diseases
- blood tests:vitamin B12\< 150 pmol/l, serum creatinine\> 250 mol/l, hypothyroidism and syphilis
Key Trial Info
Start Date :
October 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2008
Estimated Enrollment :
166 Patients enrolled
Trial Details
Trial ID
NCT00164970
Start Date
October 1 2004
End Date
December 1 2008
Last Update
February 3 2009
Active Locations (1)
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1
The Chinese University of Hong Kong
Hong Kong, Hong Kong, China