Status:
COMPLETED
Multi-Center Prospective Randomized Trial Comparing Standard Esophagectomy Against Chemo-Radiotherapy for Treatment of Squamous Esophageal Cancer - Early Results From the Chinese University Research Group for Esophageal Cancer (CURE)
Lead Sponsor:
Chinese University of Hong Kong
Conditions:
Esophageal Cancer
Eligibility:
All Genders
18-75 years
Phase:
PHASE3
Brief Summary
A multicenter randomized comparison of primary esophagectomy against definitive chemoradiotherapy for the treatment of squamous esophageal cancer.
Detailed Description
Cancer of the oesophagus is notorious for its grave prognosis with an overall 5-year survival rate of 10-20%. Surgical resection with curative intent remains the most effective treatment for this dise...
Eligibility Criteria
Inclusion
- mid or lower thoracic esophageal cancers that were confirmed on histology to be a squamous cell carcinoma deemed to be resectable
Exclusion
- distant metastasis to solid visceral organs
- local invasion into trachea, descending aorta or recurrent laryngeal nerve.
- patients \> 75 years
- serious premorbid condition
- poor physical status that compromised a thoracotomy
- compromised cardiac function
- creatinine clearance less than 50 ml/min were not eligible.
Key Trial Info
Start Date :
July 1 2000
Trial Type :
INTERVENTIONAL
End Date :
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT00165061
Start Date
July 1 2000
Last Update
September 14 2005
Active Locations (1)
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1
Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong
Hong Kong, China