Status:
COMPLETED
Genotoxicity Assessment for Patients Undergoing Radiation Treatment
Lead Sponsor:
Yuhchyau Chen
Collaborating Sponsors:
National Institute of Allergy and Infectious Diseases (NIAID)
Conditions:
Neoplasms
Eligibility:
All Genders
18+ years
Brief Summary
The purpose of the research study is to evaluate an automated, laser-based technique for measuring DNA damage caused by radiation during cancer treatment in immature red blood cells.
Detailed Description
Correlative studies: analysis of RT effect on genotoxicity by assessing cytogenetic changes (dicentrics), micronucleated lymphocytes (MN-lymph), and micronucleated reticulocytes (MN-RET) using periphe...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Patients that are scheduled to begin radiotherapy to the large-field chest region are eligible if:
- Daily radiation dose is between 1.8 and 5 Gy/day
- Any single dimension of field size is ≥ 15 cm
- Provision of written informed consent
- or
- Or patients receiving IMRT or Tomotherapy, when low-dose radiation is spread out to the normal tissues, irrespective of daily radiation doses.
- Or patients receiving radionucleotides as part of the medical treatment (cancer or non-malignant conditions)
- Or patients who will receive diagnostic CT scans, PET/CT scans, mammograms, or diagnostic imaging requiring radionucleotides
Exclusion
Key Trial Info
Start Date :
April 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 23 2024
Estimated Enrollment :
47 Patients enrolled
Trial Details
Trial ID
NCT00167427
Start Date
April 1 2006
End Date
February 23 2024
Last Update
March 7 2024
Active Locations (1)
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1
University of Rochester, Dept. Radiation Oncology
Rochester, New York, United States, 14642