Status:
COMPLETED
Effects of Venlafaxine on Chronic Neuropathic Pain Following Spinal Cord Injury
Lead Sponsor:
US Department of Veterans Affairs
Conditions:
Neuropathic Pain
Pain
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
The purpose of this study is to evaluate the pain-relieving effects of venlafaxine hydrochloride (Effexor) in chronic neuropathic (burning, shock-like, electric) pain after spinal cord injury (SCI). A...
Detailed Description
Persistent pain is one of the most common reasons for impaired quality of life following spinal cord injury (SCI). Although numerous interventions are often used to manage neuropathic pain following S...
Eligibility Criteria
Inclusion
- participant must be able to swallow pills
- fluent in English
- incomplete or complete spinal cord injury
- presence of at least moderately severe neuropathic pain at or below the level of injury
- spinal cord injury at least 2 year prior to entering the study
- pain for at least 6 months prior to entering the study
- spinal cord injury level above L1
- participants on anticonvulsants are considered
- approval of primary physician
Exclusion
- pregnant women, or those contemplating pregnancy
- prior history of use of Venlafaxine hydrochloride (Effexor)
- current use of MAOI medications
- persons who have a recent (past year) history of alcohol or drug abuse
- persons with a history of renal disease, heart disease or uncontrolled hypertension, liver disease or hepatic cirrhosis, active major medical or psychiatric illness
- persons with a significant post-traumatic encephalopathy from head trauma sustained at SCI
- persons with tardive dyskinesia or narrow angle glaucoma
Key Trial Info
Start Date :
June 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2008
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT00167856
Start Date
June 1 2005
End Date
August 1 2008
Last Update
March 27 2014
Active Locations (1)
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1
VA Medical Center, Miami
Miami, Florida, United States, 33125