Status:
COMPLETED
Priming rTMS In Major Depression
Lead Sponsor:
The Alfred
Conditions:
Major Depressive Disorder
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
The purpose of this study is to assist in understanding the most effective parameters for TMS in Depressive Disorders. Most research conducted has used high frequency stimulation on the left hemispher...
Detailed Description
The primary outcome measure used is the MADRS (Montgomery-Asberg Depression Rating Scale). This is administered at baseline and on a fortnightly basis. At study end response criteria is defined as a 5...
Eligibility Criteria
Inclusion
- Moderate to severe depressive symptoms as indicated as MADRS \>20
- Failure to respond to a minimum of two antidepressant medications
- No increase or initiation of new antidepressant therapy in the four weeks prior to entering the trial
Exclusion
- Have an unstable medical condition, neurological disorder or any history of seizure disorder or are currently pregnant or lactating
- Previous brain injury or surgery, any metal clips, plates or other metal items in the head, cardiac pacemaker
- In the opinion of the investigator, are a sufficient suicide risk to require immediate electro-convulsive therapy
- Have a current DSMIV diagnosis of substance abuse or dependence disorder, a diagnosis of a personality disorder or another axis 1 disorder
Key Trial Info
Start Date :
June 1 2004
Trial Type :
INTERVENTIONAL
End Date :
March 1 2007
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT00168272
Start Date
June 1 2004
End Date
March 1 2007
Last Update
April 16 2007
Active Locations (1)
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1
Alfred Psychiatry Research Centre
Melbourne, Victoria, Australia, 3004