Status:
COMPLETED
A Double-Blind Placebo Controlled Trial of Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Negative Symptoms in Schizophrenia
Lead Sponsor:
The Alfred
Conditions:
Schizophrenia
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
There is pilot data to suggest the therapeutic value of rTMS applied to the left prefrontal cortex in the treatment of negative symptoms. Neuroimaging studies demonstrate abnormal activity in this reg...
Detailed Description
The main outcome measure used is the SANS (Scale for the Assessment of Negative Symptoms. This is a semi strucutured interview which provides scores from 0-70. This is administered at baseline, week 2...
Eligibility Criteria
Inclusion
- DSM-IV diagnosis of schizophrenia or schizoaffective disorder, age over 18
- Persistent negative symptoms of moderate to severe intensity
- Failure to respond to a minimum of two antipsychotic medications
- No increase or initiation of new antipsychotic therapy in the four weeks prior to entering the trial
Exclusion
- Prominent positive symptoms
- Have an unstable medical condition, neurological disorder or any history of seizure disorder or are currently pregnant or lactating
- Previous brain injury or surgery, any metal clips, plates or other metal items in the head, cardiac pacemaker
- Subjects at high risk of violence or suicide as determined by the investigator and treating clinicians
- Substance dependence
Key Trial Info
Start Date :
August 1 2002
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2007
Estimated Enrollment :
22 Patients enrolled
Trial Details
Trial ID
NCT00168311
Start Date
August 1 2002
End Date
July 1 2007
Last Update
May 14 2012
Active Locations (1)
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1
Alfred Psychiatry Research Centre
Melbourne, Victoria, Australia, 3181