Status:
COMPLETED
Monoamine Oxidases in Smoking Pregnant Women and Newborns
Lead Sponsor:
Groupe Hospitalier Pitie-Salpetriere
Collaborating Sponsors:
Mission Interministérielle de Lutte contre la Drogue et la Toxicomanie (MILDT)
Mutuelle Générale de l'Education Nationale (MGEN)
Conditions:
Smoking
Pregnancy
Eligibility:
FEMALE
18+ years
Brief Summary
Smoking substantially inhibits the activities of both monamine oxidase (MAO) A and B enzymes. Aims of this study: to compare MAO activities and nicotine and cotinine in peripheral blood of smoking an...
Detailed Description
40 pregnant smoking and 40 pregnant nonsmoking women will be included at the end of the 2nd trimester. Assessments: smoking characteristics, plasma cotinine, DHPG, DOPAC, 5HIAA concentrations reflect...
Eligibility Criteria
Inclusion
- pregnancy of 5 or 6 months
- nonsmokers: lifetime smoking of less than 100 cigarettes; smokers: unable to stop smoking during the first 3 months of pregnancy; smoking at least 10 cigarettes/day.
Exclusion
- pathological pregnancies
- opioid dependence; alcoholism.
- chronic psychiatric, hematological, neurological disorders
- eclampsia
- chronic antidepressant or neuroleptic treatment
- current nicotine replacement therapies
Key Trial Info
Start Date :
March 1 2004
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 1 2007
Estimated Enrollment :
59 Patients enrolled
Trial Details
Trial ID
NCT00169390
Start Date
March 1 2004
End Date
November 1 2007
Last Update
March 19 2015
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