Status:
TERMINATED
Peripheral and Coronary Endothelial Dysfunction In Type 2diabetic Patients- Role of Metformin
Lead Sponsor:
Hospices Civils de Lyon
Conditions:
Coronary and Peripheral Endothelial Dysfunction
Eligibility:
All Genders
18-70 years
Phase:
PHASE3
Brief Summary
Peripheral and coronary endothelial dysfunction in type 2 diabetic patients may be influenced by therapeutics. Using Radial flow monitoring and myocardial perfusion magnetic resonance imaging, we desi...
Eligibility Criteria
Inclusion
- 18-70 years old, type 2 diabetes, non significant coronary atherosclerosis on inclusion coronary angiogram (ie no coronary stenosis \> 70%), HbA1c\<9%
Exclusion
- significant coronary stenosis (\>70%), lack of informed consent, unstable hypertension, renal failure, contra-indication to metformin or gliclazide, pregnancy, atrial fibrillation, contraindication to MRI, or to adenosine, brachial artery calcifications
Key Trial Info
Start Date :
October 1 2005
Trial Type :
INTERVENTIONAL
End Date :
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00169624
Start Date
October 1 2005
Last Update
October 5 2007
Active Locations (1)
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1
Laurent SEBBAG
Lyon, France, 69677