Status:
COMPLETED
Study to Compare the Effect of Valsartan vs Atenolol on Pro-thrombotic State in Hypertensive Patients.
Lead Sponsor:
Novartis
Conditions:
Hypertension
Eligibility:
All Genders
18-75 years
Phase:
PHASE4
Brief Summary
A study to compare the effects of Diovan or Atenolol taken for 12 weeks on platelet function of patients who have mild to moderately severe hypertension
Eligibility Criteria
Inclusion
- Male or female, aged between 18 - 75 years of age inclusively.
- Mild to moderate hypertension (MSDBP \>= 95 and \>= 110 mmHg and / or MSSBP \>140mm Hg) at visit 1, requiring pharmacological intervention. For newly diagnosed patients, hypertensive blood pressure values must be noted on at least two successive examinations prior to entry into the study. In addition, patients must require therapy despite having been following dietary \& lifestyle advice for at least 3 months.
- Written informed consent to participate in the study, prior to any study procedures.
- Ability to communicate and comply with all study requirements
Exclusion
- o Uncontrolled hypertension defined as seated blood pressure of either systolic BP \>180 mmHg and/or diastolic BP \>110mmHg.
- Clinically significant laboratory abnormalities that may interfere with the assessment of safety and/or efficacy of the study drug
- Patients with severe medical condition(s) that in the view of the investigator may prohibit participation in the study
- Renal artery stenosis
- Diabetes Mellitus
- Any condition resulting from or leading to platelet or clotting abnormalities (eg. hemophilia, von Willebrand's disease).
- History of a vascular event or intervention (e.g. MI, PTCA or CABG) within 6 months preceding the study.
- History of clinically significant angina, LVH, transient ischemic attack, stroke, intermittent claudication, deep vein thrombosis (DVT), pulmonary embolism or peripheral vascular disease.
- Uncontrolled atrial fibrillation (\>100 b.p.m. at rest) or other conditions which may require anti-aggregant or anti-vitamin K therapies.
- Clinical evidence of congestive heart failure.
- Evidence of second or third degree heart block or sick sinus syndrome.
Key Trial Info
Start Date :
June 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2006
Estimated Enrollment :
92 Patients enrolled
Trial Details
Trial ID
NCT00171756
Start Date
June 1 2004
End Date
March 1 2006
Last Update
February 23 2017
Active Locations (1)
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1
Novartis
Basel, Switzerland