Status:
COMPLETED
Comparison of Oxidative Stress and Insulin Resistance Before and After Using Physioneal in Peritoneal Dialysis Patients
Lead Sponsor:
National Taiwan University Hospital
Collaborating Sponsors:
Baxter Healthcare Corporation
Conditions:
Kidney Failure,Chronic
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
Patients affected by end-stage renal disease (ESRD) are subjected to enhanced oxidative stress, as a result of reduced anti-oxidant systems and increased pro-oxidant activity. Besides, insulin resista...
Detailed Description
Patients affected by end-stage renal disease (ESRD) are subjected to enhanced oxidative stress, as a result of reduced anti-oxidant systems and increased pro-oxidant activity. Enhanced oxidative stres...
Eligibility Criteria
Inclusion
- Older than 18 years old, younger than 70 years old
- Non-diabetic ESRD patients, e.g. chronic glomerulonephritis, hypertensive nephrosclerosis, interstitial nephritis, polycystic kidney disease, etc.
- Undergoing CAPD for at least 3 months and less than 60 months
- Kt/Vurea (normalized by Watson's method) is greater than 1.7, and serum albumin is greater than 3.5 g/dL
Exclusion
- Unstable clinical conditions or evidence of malignancy
- Diabetes mellitus
- Pregnancy
- Have peritonitis in recent 3 months or other active bacterial infections
- Taking any medication known to markedly interfere oxidative stress, e.g. large dose of vitamin C (greater than 500 mg/day) or vitamin E (greater than 400 IU/day).
- Medical history of systemic lupus erythematosus or rheumatoid arthritis
- Serum potassium is less than 3.0 mEq/l
- Participate in another study that would interfere with the outcome of this study
Key Trial Info
Start Date :
September 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2006
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00172211
Start Date
September 1 2005
End Date
December 1 2006
Last Update
May 7 2008
Active Locations (1)
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1
Taiwan Universithy Hospital
Taipei, Taiwan