Status:
COMPLETED
Somatropin Therapy In Children Born Preterm But Appropriate For Gestational Age
Lead Sponsor:
Pfizer
Conditions:
Growth Hormone Therapy
Infant, Very Low Birth Weight
Eligibility:
All Genders
4-10 years
Phase:
PHASE2
Brief Summary
Safety and efficacy of Somatropin will be evaluated in short children born with a list weight below 1500 g and that did not catch up to normal height at the age of 4.
Eligibility Criteria
Inclusion
- Subjects must meet all of the following inclusion criteria to be eligible for enrollment into the trial:
- Prepubertal caucasian boys between 4 and 10 years of age and girls between 4 and 9 years of age.
- Girls: Tanner stage 1 breast development
- Boys: Testis volume \<= 3ml
- Tanner stage 1 pubic hair development (to exclude confounding effect of adrenarche on growth velocity, insulin sensitivity and body composition).
- (In case of any signs or symptoms of gonadal puberty a GnRH-Test must decide if the subject is still pubertal.)
- Height \<=-2 SD for chronological age (Brandt/Reinken).
- Growth velocity SDS below 0 SD for chronological age (Brandt/Reinken based on 12+/- 3 months observation period before screening).
- Premature born defined as \<=1500 g birth weight.
- GH sufficiency (GH level \> 7 ug/l following any routine GH stimulation test).
- Written informed consent of both parents (legal guardians) and oral/written consent of subject due to age specific information.
Exclusion
- Subjects presenting with any of the following will not be included in the trial:
- Other endocrine diseases except for well substituted hypothyroidism.
- Severe chronic diseases or medication that might influence linear growth or insulin sensitivity (e.g. Glucocorticoids).
- Positive GAD and IA-2 antibodies (for type 1 diabetes).
- History of malignancy
- Children who meet all of the following 4 criteria:
- actual body height \< -2,5 SDS (Brandt/Reinken) and parent adjusted target height \< -1 SDS (Hermanussen and Cole, 2003)
- length and/or body weight retardations adjusted to gestational age at birth \< -2,0 SDS (Lawrence et al., 1989, Voigt et al., 1996)
- children with chronological age \> = 4 years and
- growth velocity \< 0 SDS during the last year before inclusion.
- Chromosomal aberrations or syndromes.
- Suspected non-compliance or impossibility to follow the two or three year treatment schedule, respectively (e.g. social implications).
- Severe hemiparesis and severe CNS defects
- Retinopathia \> third degree or laser treatment as newborns.
- Participation in any other clinical trial during active treatment phase.
- Other severe acute or chronic medical or psychiatric condition or clinically relevant laboratory abnormality that may increase the risk associated with trial participation or investigational product administration or may interfere with the interpretation of trial results and, in the judgement of the investigator, would make the subject inappropriate for entry into this trial.
Key Trial Info
Start Date :
August 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2010
Estimated Enrollment :
33 Patients enrolled
Trial Details
Trial ID
NCT00174460
Start Date
August 1 2005
End Date
March 1 2010
Last Update
April 5 2017
Active Locations (8)
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1
Pfizer Investigational Site
Chemnitz, Germany, 09009
2
Pfizer Investigational Site
Cologne, Germany, 50937
3
Pfizer Investigational Site
Erlangen, Germany, 91054
4
Pfizer Investigational Site
Freiburg im Breisgau, Germany, 79106