Status:
COMPLETED
Hypoxia Impairs Endothelial Function in HAPEs
Lead Sponsor:
Heidelberg University
Conditions:
Healthy
Eligibility:
All Genders
18-55 years
Phase:
PHASE1
Brief Summary
Aim of the study is to investigate the function of the systemic vascular endothelium in individuals susceptible to high-altitude pulmonary oedema during normoxia and normobaric hypoxia.
Detailed Description
Rationale: High-altitude pulmonary edema (HAPE) is characterized by excessive pulmonary vasoconstriction and is associated with decreased concentrations of nitric oxide (NO) in the lung. Objectives: W...
Eligibility Criteria
Inclusion
- Healthy, male volunteers, age: 18-55
- \- Able and willing to give written informed consent
Exclusion
- Known condition causing endothelial dysfunction (e.g. diabetes, hyperlipidaemia, arterial hypertension, smoking, hyperhomocysteinaemia)
- Regular medication and/or treatment with drugs within the last 4 weeks (exclusion has to be decided in each case)
- Acute or chronic illness
- Participation in clinical trial/blood donation within 2 month before the study
- Nicotine, drug and/or alcohol abuse.
Key Trial Info
Start Date :
Trial Type :
INTERVENTIONAL
End Date :
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00176007
Last Update
September 15 2005
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