Status:
COMPLETED
BlueCQ Bioavailability
Lead Sponsor:
Heidelberg University
Conditions:
Methylene Blue
Chloroquine
Eligibility:
All Genders
18-50 years
Brief Summary
Bioavailability of methylene blue (MB) - comparison of an i.v. and two oral MB formulations - and influence of sustained release MB on chloroquine (CQ) concentrations in whole blood, plasma and urine....
Detailed Description
Maximum whole blood methylene blue (MB) concentrations after i.v. and oral administration may differ in the magnitude of 100:1. For achieving MB concentrations possibly effective against malaria when ...
Eligibility Criteria
Inclusion
- Good state of health physically and mentally
Exclusion
- Any regular drug treatment currently or past (within the last 2 months) except for oral contraceptives in females Treatment with a known inhibitor or inducer of drug metabolising enzymes or transport proteins within a period of less than 10 times the respective elimination half-life
- Any acute or chronic illness, especially:
- Glucose-6-phosphate dehydrogenase deficiency Allergic disposition or history of hypersensitivity reactions Smoking Alcohol or drug abuse
Key Trial Info
Start Date :
August 1 2004
Trial Type :
OBSERVATIONAL
End Date :
November 1 2004
Estimated Enrollment :
18 Patients enrolled
Trial Details
Trial ID
NCT00176072
Start Date
August 1 2004
End Date
November 1 2004
Last Update
September 15 2005
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