Status:
COMPLETED
Pharmacokinetics of THCCOOH and Its Acyl-glucuronide After Intravenous Administration of THCCOOH
Lead Sponsor:
Heidelberg University
Conditions:
THCCOOH
Pharmacokinetics
Eligibility:
MALE
18-50 years
Brief Summary
A study on the fate and elimination of 11-Nor-Delta9-carboxy-9-tetrahydrocannabinol was up to now not conducted, except of one single experiment in which (lacking) psychopharmacological activity was t...
Detailed Description
To determine the pharmacokinetics of THCCOOH after intravenous administration of THCCOOH (5 mg) and its formed glucuronide in healthy individuals in order to improve the possibilities for the assessme...
Eligibility Criteria
Inclusion
- Good state of health (physically and mentally)
Exclusion
- Any regular drug treatment within the last two months
- Any intake of a substance known to induce or inhibit drug metabolising enzymes or transport systems within a period of less than 10 times the respective elimination half-life
- Any acute or chronic illness or clinically relevant findings in the pre-study examination
- Allergies (except for mild forms of hay fever) or history of hypersensitivity reactions
- Smoking (regular or irregular)
- Excessive alcohol drinking (more than approximately 30 g alcohol per day)
- Positive drug screening especially THC or known or admitted drug abuse
Key Trial Info
Start Date :
October 1 2004
Trial Type :
OBSERVATIONAL
End Date :
March 1 2005
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT00176085
Start Date
October 1 2004
End Date
March 1 2005
Last Update
May 28 2015
Active Locations (1)
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1
Clinical Research Center, Department of Internal Medicine VI
Heidelberg, Germany, 69120