Status:
COMPLETED
Impact of Exercise Training on Exercise Capacity in Patients With Severe Chronic Heart Failure
Lead Sponsor:
University of Leipzig
Collaborating Sponsors:
Deutsche Stiftung für Herzforschung
Conditions:
Heart Failure
Eligibility:
MALE
18-75 years
Phase:
PHASE2
Brief Summary
Patients with heart failure are limited in their exercise capacity due to skeletal muscle alteration and an impairment of peripheral perfusion. Regular physical exercise training has been shown to par...
Detailed Description
A total of 36 patients with severe chronic heart failure are prospectively randomized to either 3 months of aerobic ergometer training or a sedentary control group. Before and after the intervention ...
Eligibility Criteria
Inclusion
- chronic heart failure (NYHA class III b)
- peak oxygen uptake \<20 mL/min/kg body weight
- left ventricular ejection fraction \<25 %
- left ventricular end-diastolic diameter \>60 mm
Exclusion
- exercise-induced myocardial ischemia
- cardiac decompensation within the last 8 weeks
- ventricular arrhythmias (\>Lown 4b) in patients not protected by an ICD
- insulin-dependent diabetes mellitus
- uncontrolled arterial hypertension
- orthopedic conditions excluding training participation
- body mass index \>30 kg/m2
Key Trial Info
Start Date :
March 1 2003
Trial Type :
INTERVENTIONAL
End Date :
December 1 2006
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT00176384
Start Date
March 1 2003
End Date
December 1 2006
Last Update
August 1 2007
Active Locations (1)
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1
University of Leipzig, Heart Center, Department of Internal Medicine / Cardiology
Leipzig, Saxony, Germany, 04289