Status:
TERMINATED
Change in Thrombin Generation Potential and Thromboelastography During the Menstrual Cycle
Lead Sponsor:
The University of Texas Health Science Center, Houston
Collaborating Sponsors:
The ZLB Behring Foundation
Conditions:
Von Willebrand Disease
Eligibility:
FEMALE
18-50 years
Brief Summary
The primary objective of this study is to describe characteristics and trends for thrombin generation (TG) and thromboelastography (TEG) at 4 time points during the menstrual cycle.
Detailed Description
We propose that TG and TEG will be more sensitive than traditional coagulation assays to detect physiologic variation in hemostasis, fibrinolysis, and platelet activation throughout the menstrual cycl...
Eligibility Criteria
Inclusion
- Females of reproductive age with regular menstrual cycles and a diagnosis of von Willebrand disease according to the International Society of Thrombosis and Hemostasis diagnostic criteria.
Exclusion
- Females who are pregnant, or have a history of endocrinopathy or hormone imbalance
- History of hysterectomy or bilateral oophorectomy
- History of ovarian or uterine cancer
- Use of intrauterine device
- Use of antifibrinolytic therapy, hemostatic agents, or anti-platelet agents.
Key Trial Info
Start Date :
September 1 2005
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 1 2013
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00178542
Start Date
September 1 2005
End Date
April 1 2013
Last Update
May 6 2013
Active Locations (1)
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1
The University of Texas Health Science Center at Houston
Houston, Texas, United States, 77030