Status:
TERMINATED
Enteral Glutamine Supplementation for the Patient With Major Torso Trauma
Lead Sponsor:
The University of Texas Health Science Center, Houston
Collaborating Sponsors:
National Institutes of Health (NIH)
Conditions:
Trauma
Critical Illness
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
Glutamine is considered a conditionally essential amino acid during critical illness. After severe trauma, glutamine supplementation into the gastrointestinal tract may help maintain bowel function. W...
Detailed Description
In this prospective, randomized, controlled trial of patients with major torso trauma, high-dose enteral glutamine and enteral nutrition will be given to research subjects while controls will receive ...
Eligibility Criteria
Inclusion
- Adult trauma patients meeting criteria for shock resuscitation
- Major torso trauma
- Admission to the Shock/Trauma Intensive Care Unit
Exclusion
- Age \<18 years
- Pregnant
- Expected survival \< 24 hours
- Bowel in discontinuity
- Renal failure: baseline serum creatinine\>3.0 and/or dialysis
- Admission total bilirubin \>10 mg/dl
- History of cirrhosis or cirrhosis apparent on exploratory laparotomy
- Asystole or CPR required
Key Trial Info
Start Date :
June 1 2005
Trial Type :
INTERVENTIONAL
End Date :
September 1 2006
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00178581
Start Date
June 1 2005
End Date
September 1 2006
Last Update
April 23 2010
Active Locations (1)
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1
University of Texas Health Science Center at Houston
Houston, Texas, United States, 77030